The learning process in the university and the environment on campus have a crucial role in the development of students' psychological and physical well-being. The present study aims to highlight the problems of online classes faced by university students during the period of the COVID-19 pandemic. It also examines the factors of online classes that caused depression among Pakistani students. The data was collected through an online survey and students were asked to fill survey comprised of perception sand problems of online classes and Patient Health Questionnaire-9. A total of 820 students were approached. Among them, 734 (89.51 Percent) had completed the survey. The results showed that most of the students had moderately (31.34 Percent) or moderately severe (24.39 Percent) depressive symptoms because considerable problems occurred in their educational learning process due to online classes amid the COVID-19 pandemic. It is concluded that emotional support is necessary for the well-being of students as a study examining the COVID-19outbreak has an extraordinary burden on university students.