Recent history of international relations suggests that economic interdependence largely contributes to the mitigation of the major political conflicts in the world. CPEC, a flagship mega development project of Belt and Road Initiative (BRI), has not only initiated massive development projects in Pakistan, which will eventually help in socio-economic development of Pakistan but it will also ensure regional integration. Development of Pakistan through CPEC is desirably focused on a people centric growth model that primarily seeks to resolve the issues of human security. This paper seeks to establish the relationship between economic interdependence and regional integration with human security. Furthermore, this study looks into the role of Gilgit-Baltistan, a geographical lynchpin region, in making CPEC a successful developmental project. Findings of the study suggest that the viability and success of this mega project is highly dependent on the inclusiveness of projects in terms of engaging all stakeholders. The fruits of this mega project are expected to be positive. This is only possible if all the different dimensions of national security, i.e. social cohesion, economic development, and political stability are ensured by the state.