Great power is a sovereign state that is recognized as having the ability and expertise to exert its influence on a global scale. Great powers characteristically possess military and economic strength, which inspires states to enhance influence in strategically important regions. The Middle East region has always remained the centre of attraction for major powers due to its geostrategic importance and huge energy resources. The civil war in Syria is a prolonged armed conflict that began in 2011. U.S and Russia, being involved from the beginning in the conflict, have different interests and campaigns. Over the last four decades, another most important region has become a source of turmoil and unease, Afghan crises in the region that has always persisted as the source of concern for the global powers and a cornerstone for regional powers. Moscow's mistake to intervene in Afghanistan revealed its unassailable vulnerability. After the Soviet Union disintegration, Kabul has again become the focal point of US policy in the region post 9/11 terror attacks.