The macroeconomic version of the APT is of great significance in examining the return on assets. It analyzes the estimated security return with reference to various macroeconomic variables. Despite availability of research studies related to the developed and emerging stock markets of the world, still a research gap exists for exploring the frontier markets like equity market of Pakistan. The study examines the long and short term impact of macroeconomic variables on the KSE 100 index for the period of July 1996 - June 2015. Cointegration technique and VECM models have been applied. Among these variables, GDP, inflation, exchange rate, unemployment rate, labor force cost and stock market of US were found significant for explanation of effects on return of stock market of Pakistan. The study findings have potential implications for both policymakers and investors pertaining to macroeconomic factors and stock market volatility.