Higher education plays a vital role in developing the knowledge economy and producing skilled workers to empower human resources for the country. Like many other developing countries, Pakistan is struggling hard to improve the quality of higher education for sustainable development and participation in global progress. Since the last decade, Higher Education Commission Pakistan is committed to upgrading the quality of education, and for this purpose, HEC has designed Minimum Quality Standards (MQS) to assure quality for affiliated institutions. The main objective of the study was to evaluate R&D practices in affiliated institutions of Pakistan. The study was descriptive in nature, and a questionnaire based on Minimum Quality Standards was used to collect data from faculty members (n-168) of 28 affiliated institutions by using multistage sampling. The results indicated that affiliated colleges of two provinces, Punjab and Khyber Pohutukawa, were better in research and development practices than the institutions of Sindh and Baluchistan.