The present qualitative study aimed in-depth exploration of dyadic coping among couples dealing with chronic illness. There were 12 couples (six females and six males) with chronic illness and their healthy partners were interviewed. The in-depth interviews were conducted through interview guide based on Systematic Transactional Model (STM) (Bodenmann, 1995) and lived experiences of participants. The results were analyzed by using (Braun & Clarke, 2006) method of thematic analysis. The results revealed that female diagnosed partners showed less supportive dyadic coping to deal with physical and emotional burden of their chronic illnesses as compared to chronically ill male partners. However, the economic hardships is equally stressful for both members of the couples resulted in negative dyadic coping. The therapeutic assistance should be given to improve the dyadic coping among couples to deal with burden of chronic illness and live with better quality of life.