This study compared the perception(s) of teachers and headteachers working in special schools and those in regular schools about the effect of leadership on the performance of the school. The sample included 100 teachers and 50 headteachers from each of the school categories in Karachi city. The analysis of data was carried out by using descriptive statistics and Independent Samples t-test. The results revealed that teachers and headteachers perceived leadership style to be affecting the performance of the school. The headteachers and teachers from regular schools and teachers from special schools scored highest on their response(s) demonstrating that headteachers anticipated the role teachers working under their leadership in inculcating knowledge, skills, and attitudes among students; whereas, the score of the responses of the headteachers of special schools appeared to be highest indicating that they guide their teachers how to attain the goals of their school(s).