This paper critically analyses the US and Pakistan relations in historical context and thereby comprehends the causes of misunderstandings between them, especially under the new administration of Donal Trump. Like other states in our world both Pakistan and USA have priorities to secure their national interests as both have their own way of protecting their interest in short, medium or long terms. The paper finds that unlike the US which makes a policy that focuses only on the current scenarios, Pakistan keeps in view the lessons from past betrayals from US and her future needs arising from her security issues related to her neighbours i.e. Afghanistan and India. Pakistan also fears Indian involvement in Afghanistan and the US support to India in Afghanistan in general and particularly in the region. Pakistan needs to understand US mistrust for rapid proliferation (even legal) to earn easy money to strengthen its weak economy. From the US perspectives, it strategy regarding Pakistan is no different from that of a major powers as she only focuses short terms objectives. USA needs to realize that the strategic location of Pakistan and the nuclear capability makes her an important country that bestows on her the right to be treated like medium power in the region. It not only about dealing with mutual misunderstandings related to realization of mutual concerns but it is also about peace, security and future of every sixth human being on earth who lives in the region or maybe its impacts can go far beyond to the whole world. Therefore, both Pakistan and the US need to address each other's concern and work on converging lines.