Health communication characterizes the boundary between communication and health and is progressively documented as essential for everyday well-being. Mass media, especially electronic media, is the need of the time, especially during the outbreaks like Polio in Pakistan. People get information from mass media, up-grade their knowledge, and their attitudes are formed, and ultimate change in practices becomes forth. By keeping in view the widely witnessed role of mass median healthcare communication, this article also examines Pakistan regarding Polio eradication. We executed a descriptive quantitative method and gathered data from n= 300 respondents. Results revealed that Mass Media and Interpersonal communication have a significant role in delivering the proper knowledge about the Polio disease. Through Mass Media and Interpersonal Communication, the masses may know the harmful consequences of Polio disease and the influential role of the vaccine inuring this disease. Thus, we concluded that media help eradicate misconceptions about the vaccine, resulting in the complete wipe out of Polio from Pakistan. Further, we have discussed the results and highlighted the recommendations accordingly.