The Outbreak of COVID-19 has caused distress all around the world. The healthcare professionals significant risk of transmitting coronavirus to others. This research determines the predictive effects of thanatophobia on psychological distress among healthcare workers during COVID-19. The demographic differences were related to age, gender, job title, and year of experience examined in the study variables. The data were collected on the Kessler Psychological Distress Scale and the Templer’s Death Anxiety Scale from doctors, nurses, and paramedical staff in different hospitals of District Haripur, KPK Pakistan via a convenient sampling technique. Findings showed that thanatophobia predicted a 33.5% increase in psychological distress. Women and doctors were more phobic and distressed than men, nurses, and paramedical staff. The older workers with more job experience had high thanatophobia and low psychological distress than their counterparts. The study’s limitations and recommendations are discussed.