For the last few months, COVID-19 has had a significant effect on clinical laboratory. This formalized with existing issues and difficulties for the laboratory evaluation of infections owing to extreme acute coronaviral syndrome 2 (SARS-CoV-2). The selection of the relevant respiratory tract specimen from the appropriate anatomical position is key to a timely and correct molecular diagnosis of COVID-19 at the right time in the pre-analytical process. Suitable steps are needed to safeguard laboratory personnel in order to provide accurate test results. The article is aimed at reviewing the literature related to the diagnosis and treatment therapy adapted to compete for novel coronavirus. The study is followed by reviewing 40-45 articles to critically evaluate and extract the possible therapies adapted in the different regions of the world. Serology, radiotherapy, antigen-detection test, point-of-care molecular diagnostics and other radiotherapeutic approaches are found to be efficient and used in several regions of the world.